Disodium-Citrate-Glucose Mixture as a Blood Preservative.

Dimensional, Osmotic, and Chemical Changes of Erythrocytes

Previous studies have indicated that acid glucose-citrate solutions provide the best preservation available at the present time (1). The mixture proposed by Loutit and Mollison (2, 3), conventionally called ACD-I in the United States, has been most extensively studied and appears unsurpassed in its preservative qualities. It is added in amounts of 25 ml. per 100 ml. of blood. The study to be re...

The introduction of citrate as an anticoagulant for transfusion and of glucose as a red cell preservative.

In 1918, Oswald Robertson published a remarkable paper, describing transfusions of stored red cells given near the front line in France in the First World War (Robertson, O.H., 1918a). Only 4 years had elapsed since the ®rst few transfusions of citrated blood had been given to human subjects; the method of storage which was used had not previously been applied to transfusion in humans. For the ...

Erythrocyte preservation. VII. Acid-citrate-dextrose-inosine (ACDI) as a preservative for blood during storage at 4 degree C.

Rate of Glucose Utilization by Blood Cells in Serum and Plasma Specimens With or Without Using Preservative

Objective: This study aims to estimate and compare the time-course change in blood glucose levels by blood cells in serum, and plasma with or without preservatives, which may reflect the rate of glucose utilization by blood cells. Method: This laboratory-based cross-sectional study was carried out using a blood specimen of 28 participants among which 14 were diagnosed with diabetes and 14 were...

An Acid Citrate-dextrose Solution with Low Water Volume and Low Dextrose Concentration.

The blood preservative introduced by Loutit and Mollison (1) consisting essentially of a sodium citrate-dextrose mixture of relatively low pH, has proved superior to previously employed preserving fluids. The original formula and many subsequent modifications have a rather high volume. This produces considerable dilution of the plasma proteins. The purpose of this study, begun in June 1944, was...